ABSTRACT. Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and. Abstract: Inositol hexaphosphate (IP6) is a naturally occur- ring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain. While IP-6 is found in rice bran and other foods, there are good reasons to take an IP-6 & Inositol supplement. First, IP-6 is getter absorbed in pure form without.

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Citing articles via Google Scholar. Absorption and excretion of orally administered inositol hexaphosphate IP 6 or phytate in humans. Using a novel and highly sensitive method combining gas chromatography—mass spectrometry analysis and HPLC, Grases et al. Novel anti-cancer functions of IP 6: A reduced tumor growth rate was noticed overall and in some cases a regression of lesions was noted.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

Although IP 6 may belong to almost all previously mentioned categories of cancer preventive drugs, affecting almost all phases of cancer prevention, it still appears that IP 6 inositop not a direct antagonist to the carcinogen because of its moderate efficacy in vitro when tested and compared with other chemopreventive agents 30 and a lack of dramatic decrease in cancer incidence when tested in vivo.

Analyzing absorption, intracellular distribution, and metabolism of IP 6 in HT human colon carcinoma and cells of hematopoietic lineage K, human erythroleukemia and YAC-1, mouse lymphoma cellswe found that IP 6 is rapidly taken up by mechanisms probably involving pinocytosis or receptor-mediated inosktol, transported intracellularly, and dephosphorylated into lnositol phosphates with fewer phosphate groups Inhibition i6 mammary gland carcinogenesis by green tea catechin and other naturally occuring antioxidants in Sprague-Dawley rats pretreated with 7,dimethylbenz[ a ]anthracene.

A novel anticancer function of inositol hexaphosphate IP 6 ; 4 also Ins P 6 and phytic acid has been shown both in vivo and in vitro 3 — 5.

However, because cancer prevention is a long process, a long administration of cancer preventive agent is generally needed, requiring usually 10—40 y of continuous treatment 273and, therefore, it is very important that cancer preventive agents have low or almost no toxicity.

It was also hypothesized that the addition of inositol, a precursor of inositol phosphates and also a natural carbohydrate, to IP 6 may enhance the anticancer function of IP 6 18 — Many tumors produce large amounts of vascular endothelial growth factor, a cytokine that inositpl normal blood vessels to grow. Inositol hexaphosphate and inositol inhibit DMBA-induced rat mammary cancer.


However, recent studies demonstrate that this antinutrient effect of IP 6 can be manifested only when large quantities of IP 6 are consumed in combination with a diet poor in oligoelements 60 — The most consistent and best anticancer results were obtained from the combination of IP6 plus inositol.

Using highly invasive MDA-MB human breast cancer cells, we demonstrated that IP 6 inhibits metastasis in vitro through effects on cancer cell adhesion, migration, and invasion 70 However, IP 6 causes the accumulation of human leukemia cells in the G 2 M phase of the cell cycle; a cDNA microarray analysis showed a down-modulation of multiple genes involved in transcription and cell-cycle regulation by IP 6 Effects of dietary myo-inositol or phytic acid on hepatic concentrations of lipids and hepatic activities of lipogenic enzymes in rats fed on corn starch or sucrose.

These data indicate that the intact molecule was transported inside the gastric epithelial cells, wherein it was rapidly dephosphorylated, and that the metabolism of IP 6 was very rapid. However, cells from different origin have different sensitivity to IP 6 the leukemic cell lines seem to be highly susceptible to IP 6suggesting that IP 6 may affect different cell types through different mechanisms of action.

Derivatives of phosphatidylinositol transmit cellular signals in response to extracellular stimuli, and enzymes responsible for the phosphorylation and hydrolysis of these signaling lipids play an important role in a broad range of biological effects. IP 6 not only inhibits the activities of some liver enzymes 7576 but also significantly increases the hepatic levels of glutathione S -transferase 4477both of inositl indicate its possible role in carcinogen-blocking activities and cancer protection.

Protection against cancer by dietary IP6 and inositol.

Because inositol phosphates are common molecules involved in signal transduction in most mammalian cell systems, it was further hypothesized that the anticancer action of inositol phosphates would be observed in different cells and tissue systems 18 — Effect of fiber, phytic acid, and oxalic acid in the diet on mineral bioavailability.

Exogenously administered IP 6 is rapidly taken into the cells and dephosphorylated to lower-phosphate inositol phosphates, which further interfere with signal transduction inozitol and cell cycle arrest. Malignant and normal cells are known to have a different metabolism, inositoll rate, expression of receptors, etc. Aberrant crypts correlate with tumor incidence in F rats treated with azoxymethane and phytate. Inhibition of mammary carcinogenesis by inositol hexaphosphate phytic acid.

Chalcones, myo-inositol and other novel inhibitors of pulmonary carcinogenesis. Although experts in the field of nutrition and cancer have been performing in vivo experiments by adding IP 6 to the diet, in all inoositol cancer prevention studies, IP 6 was given via drinking water in concentrations ranging from 0.


Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials. An enhanced antitumor activity without compromising the patient’s quality of life was demonstrated in a pilot clinical trial involving six patients with advanced colorectal cancer Dukes C and D with multiple liver and lung metastasis Inositol hexaphosphate IP 6 enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer.

Enhanced immunity and antioxidant properties can also contribute to tumor cell destruction. Our recent data demonstrate that IP 6 acts synergistically with doxorubicin and tamoxifen, being particularly effective against estrogen receptor—negative and doxorubicin-resistant cell lines, both conditions that are challenging to treat IP 6 is a polyphosphorylated carbohydrate, contained in high concentrations 0.

Ivana Vucenik, AbulKalam M. The antioxidant activity of IP 6 is widely accepted and indisputable 11and IP 6 possesses antiproliferative and antiprogression activities. Apoptosis is a hallmark of action of many anticancer drugs.

In this review we show the efficacy and discuss some of the molecular mechanisms that govern the action of this dietary agent. Additionally, the preexisting liver cancers regressed when they were treated directly with IP 6 From Laboratory to Clinic Ivana Vucenik. Only myo -inositol hexaphosphate has been found in plants; neo – chiro – and scyllo -inositol hexaphosphates have been isolated from soil 7.

Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

The data strongly argue for the use of IP 6 plus inositol in our strategies for cancer prevention and treatment. IP 6 can also adversely affect angiogenesis as antagonist of fibroblast growth factor In this model experimental lung metastases are developed after intravenous injections of FSA-1 cells; intraperitoneal injections of IP 6 resulted in a significant reduction of metastatic lung colonies Therefore, the strategy of chemoprevention is to use agents that will inhibit mutagenesis, induce apoptosis, induce maturation and differentiation, and inhibit proliferation For a long time IP 6 has been recognized as a natural antioxidant.

Synergistic cancer inhibition by IP 6 when combined with inositol was observed in colon cancer Table 3 19 and mammary cancer studies Table 4 51 ,